Experienced referrals for Immune Therapies - Available Now!
A rational immune therapy approach is providing a new medical alternative for the treatment of cancer.
By harnessing the innate powers of the body’s immune system, immunotherapy treatments have the potential to achieve complete, long-lasting remissions and cures for all types of cancer.
Our personal experience with cell based immune therapies:
In short – Our patients have experienced outcomes well beyond clinical expectations:
For over 4 years, we’ve helped patients access special cell-based immune therapies – with most achieving outcomes beyond clinical expectations!
All patients can take advantage of immune therapy as a value add to other treatments or in some cases, a standalone treatment. However, before leaping in, there is one fact to understand. There is a big difference between safe cell based immune therapies & unpredictable drug based immune therapies. See 2 column comparison further down the page.
Cell based Immune therapies may hold the answer to your cancer. We encourage you to take the time to watch these informative video animations.
The particular cell-based immune therapies which played a significant role in our (stage IV) patient’s great outcomes; are little-known in Western medicine – despite being used with patients for 25+ yrs in Asia.
Consequently; when patients ask their doctors about immune therapies, they are usually told about drug based immune therapies. Cell-based vaccines; available through our international immunology-oncology colleagues (via our referrals) are unknown.
When informed about cell-based immune therapies, most Western doctors deem them ‘experimental.’
Not so – more than 10,000 clients have passed through the doors of our preferred clinic since the early 1990’s. Dozens of high quality medical papers detail the efficacy of this safe treatment.
As you read on you will learn how these types of immune therapies are made from your own harvested immune cells.
The key here is the quality of cells produced, expertise and technique and a long history using vaccines with significant numbers of patients.
Consequently: WE ONLY REFER OUR PATIENTS TO THIS ONE CLINIC – CONSIDERED BY US A WORLD LEADER IN IMMUNE THERAPIES.
“During cell based immune therapy, amongst the cancer fighting cells, the NK cells stand apart from the rest not just for their direct cytotoxic ability against cancer cells, but their added advantage which includes the capability of…
- Enlivening both innate and adaptive immune mechanisms.
- Tackling viruses as well, giving benefits in conditions where viral infections culminate in cancer (onco viruses)
- Destroying cancer stem cells, thereby preventing resistance to chemotherapy & radiotherapy
Extract from ‘International Reviews of Immunology’ vol 36, 2017 – Issue 4.
International Reviews of Immunology is an international peer-reviewed medical journal that covers basic and translational research in immunology and related fields.
Comparing drug-based immune therapies with cell-based (blood or tumour based) immune therapies
Drug based immune therapies:
These are now available worldwide – sometimes provided on Medical Trials – sometimes on a pay per dose basis.
While these types of drug-based immune therapies have demonstrated some outstanding successes particularly in Melanoma – Importantly; severe,unpredictable side effects, sometimes fatal are being reported in the medical literature.
Anti PD1 drugs designed to unleash the immune system, strip a protein (PD1) from the surface of cancer cells, making them more likely to be discovered by the immune system and destroyed.
However, the target is proven to be unreliable, with many patients experiencing their own immune system attacking vital organs as well – instead of their cancer.
Severe Side effects: Checkpoint inhibition is associated with a unique spectrum of side effects termed immune-related adverse events (irAEs).
A recent paper found that 30 percent of patients experienced “interesting, rare or unexpected side effects,” with a quarter of reactions described as severe, life-threatening or requiring hospitalisation
Positive outcomes: In melanoma and a few select cancers including non small cell lung cancer there have been amazing responses.
The downside is, the patient’s immune system may become highly unpredictable – causing severe long term side-effects or death.
Overview: As mentioned above, breakthroughs in cancer treatment create great excitement – and this was the case with the new drug-based immune therapies.
However, it is extremely important that patients differentiate between drug-based immune therapies, developed by big Pharmaceutical Companies, and the blood or tissue-based immune therapies that we organise for our patients
Background: In the case of the drug based immune therapies, once FDA approval was obtained, they were quickly and widely distributed. There was tremendous enthusiasm and massive promotion – oncologists saw them as alternatives to chemotherapies.
However; like many new medical discoveries, as the dust settled, a more realistic picture was emerging.
Many of our oncology colleagues noticed severe and unpredictable side effects, such as heart damage, in some patients on immune therapies.
Papers about the unpredictable side effects are appearing in the medical literature and warnings have been issued.
Caution: If you are considering using drug based immune therapies we recommend you read ALL the articles below. (click topic).
8. Car T Cell Therapies – sudden severe side effects – can take a small army of top specialists to keep patients alive while their newly engineered immune systems attack their cancer cells. Remains so risky, so complex, so difficult to manage that experts warn it’ll be years …
9. FDA stops Merck Trial. Keytruda immunotherapy deaths higher than control group.The decision was taken after independent safety monitors observed more deaths in patients receiving the Keytruda combination than in the control groups in two of the studies.
10. Toxicities of CAR T-Cell Therapy
Cytokine release syndrome (CRS)
The hallmark of CRS is immune activation resulting in elevated inflammatory cytokines. Clinical and laboratory measures range from mild CRS (constitutional symptoms and/or grade-2 organ toxicity) to severe CRS (sCRS; grade ≥3 organ toxicity, aggressive clinical intervention, and/or potentially life threatening). Clinical features include: high fever, malaise, fatigue, myalgia, nausea, anorexia, tachycardia/hypotension, capillary leak, cardiac dysfunction, renal impairment, hepatic failure, and disseminated intravascular coagulation – often requiring treatment in ICU.
Blood or blood tumour-based vaccines:
This is a very safe treatment method in which Natural Killer Cells (NK cells) and Cytotoxic T Lymphocyte (CTL’s) cells are taken out of a patient’s body, cultured and processed to be activated or to acquire additional functions, until their resistance to cancer is strengthened, after which the cells are re-infused back to the patient.
1. NK cells and T lymphocytes isolated from the patient’s blood are activated and expanded and then re-infused into the body. Upon encountering a tumour cell, the activated NK cell attaches to the membrane of the cancer cell and injects toxic granules that quickly dissolve the target cell.
In less than five minutes, the cancer cell is dead, and the NK cell moves on to its next target. A single NK cell can destroy up to 27 cancer cells before it dies. Many millions are infused into a patient during this process. This is the mechanism by which this type of immune treatment is effective in Cancer therapy.
Dendritic Cell vaccines are quite a popular form of Immunotherapy in which the Dendritic cells present the tumour antigens to the body’s Cytotoxic T lymphocytes for destruction of the tumour cells.
Cytotoxic T Lymphocytes from the patient themselves are directly activated, expanded in the lab and when re-infused back to the patient they can effectively act against the tumour cells.
Personalised peptide vaccines can also be made from a selection of peptides that are handpicked based on the patient’s blood and specific molecular and genetic profile.
2. Tumour lysate vaccines: There are two main immunotherapy vaccines, one called whole tumour vaccine which is derived from the patient’s whole tumour; for example a lymph node can be harvested and used to create a personalised vaccine.
This requires the patient’s tumour tissue to be preserved alive and in a sterile manner at the time of surgery. That tissue is then forwarded to a vaccine laboratory for processing. The patient then provides a white cell harvest and the manufacturing process for a personalised vaccine begins.
Side effects – virtually nil. For some, a slight fever or flu-like feeling can occur, but not always. High degree of safety and predictability.
Results Significant increase in disease free survival, complete response or static non-progressive disease could be accomplished in patients – including those with ovarian cancer, Acute Lymphoblastic leukemia, Acute Myeloid Leukemia, advanced in-operable pancreatic cancer, prostate cancer with multiple metastasis and breast cancer with metastasis and many other cancer types.
Male, 85 years old. Pancreatic cancer with multiple liver metastases.
Combination treatment with NK cells T cells, dendritic cells every two weeks
chemotherapy, (GEM 600 mg/2WEEKS), hyperthermia every week. Low Profit Margin: Finally, blood or blood tumour-based immune therapies cannot be mass produced – it’s one on one. No profits.
This contrasts with drug-based immune therapies, produced en masse by big pharmaceutical companies for huge profits.
The research data suggests that cell based immune therapies are a safe adjunct treatment modality of tackling cancer and may induce effective immune responses in cancer patients and help improve the prognosis.
The results suggests that NK cell and CTL based immune therapies combined with hyperthermia & low-dose chemotherapy was effective even in advanced cancers which were refractory to conventional therapeutic modalities… Click for PubMed
Finally: For over 4 years, the Grace Gawler Institute has helped select patients access cell-based immune therapies in Japan with consistent remarkable results. The vast majority of patients look & feel well soon after receiving treatment.
The effects of increased immune system activity can be measured. As well; safety & predictability of the therapies is excellent – commonly minimal to zero side effects. The choice is yours to make but at least it can now be an informed choice.
Restoring and building your immune system:
The video above shows how cytotoxic T cells – the body’s ‘serial killers’ – hunt down and eliminate cancer cells before moving on to their next target.
The immune therapies we organise for our patients enhance and multiply this process – safely.
Unlike the drug based immune therapies, with unpredictable and often brutal side effects, the cell based immune therapies our patients access have predictable and zero to mild side-effects.
Would you like to know how to impact the cancer killing capacity of your immune cells?
Please view the videos above to witness the miracle within us all – our immune system.
Monocytes: These are rather clever white blood cells that can change shape and function when they go foraging in your tissues looking for bacteria and cancer cells.
Called Monocytes when they are in our blood – when they travel into tissues from the blood they change shape and become macrophages or dendritic cells.
Patients in remission with no evidence of disease are strongly advised to investigate cell based immune therapy to help prevent recurrence and repair and restore their immune system after chemotherapy and other treatments.
Note: Low dose chemotherapy, monoclonal antibodies and radiation techniques such as CyberKnife, stereotactic radiation therapy, proton beam therapy etc can be used in conjunction with personalised vaccine approaches.
Summary of immune therapy differences
Drug based immune therapies:
mass produced by big pharma companies – sold globally – big profit margins
occasional excellent outcomes – especially in melanomas
side effects – highly unpredictable – ranging from mild to severe
not suitable for many cancers some great results with melanomas, liver & kidney cancers
helps only low of patients – doctors unclear why
now being used in trials for other cancers
still experimental – although FDA approved.
new side effects keep appearing as the drug-based therapies aremore widely used
long term effects still unknown
Blood or blood tissue based immune therapies:
Personalised from your cells – one patient – one doctor – low profit margins
consistent exceptional patient outcomes
side effects – predictable – ranging from low to non-existent
suitable for most cancers – except some auto-immune based cancers
not experimental – our collegiate clinic has treated 10,000 patients since 1990
value add – can safely enhance other treatments, e.g. low dose chemotherapy, hypothermia, cyber knife, proton beam therapy and stereo tactic radiation.
long term effects known – no negative outcomes observed.