Regional Hyperthermia and Immune Therapy:
Why is hyperthermia often used in combination with immune therapies?
Hyperthermia enhances immune responses and potentiates cancer treatment.
Our Japan-based immune-therapist and his team are experienced and well published on the positive effects of hyperthermia on anti-cancer immune responses that can be achieved especially when the host immune system is functioning adequately.
For this reason many patients – both early in diagnosis or, even patients with advanced cancer choose to have cell–based immune therapies BEFORE they begin a chemotherapy or chemo radio-therapy program.
In cancer patients, the number & activity of immune cells are often decreased due to immuno-suppression by the cancer itself as well as by (often) necessary therapeutic treatments such as chemotherapy & radiation.
Under such circumstances, hyperthermia should be combined with immune-potentiation in order to increase activity of anti-cancer cytotoxic immune cells and exert value-add synergistic effects. Hyperthermia treatments can also be used in combination with other cancer treatments.
How Hyperthermia helps the immune activation process:
NK cells harvested from the patient by apheresis & safely expanded in the laboratory, possess high numbers of activating NK receptors. These receive strong activation signals from NK activation ligands expressed in abundance on fever-range hyperthermia–treated cancer cells – leading to aggressive attacks on cancer cells.
Hyperthermia also induces heat shock proteins (HSPs)** in cancer cells & enhances antigen-specific cytotoxic T lymphocyte (CTL) induction via efficient cross-presentation by dendritic cells (DCs)
** Heat shock Protein – a protein induced in a living cell in response to a rise in temperature above the normal level.
Hyperthermia as a value add healing modality has a long in history in Europe, especially Germany. Research on hyperthermia in Japan was started by the Hyperthermia Study Group in 1978; then the Japanese Society of Hyperthermic Oncology (JSHO) was established.
Supported by the Japanese Government and intensively researched; access to hyperthermia for clinical use in patients in Japan has been available for some time. Hyperthermia can be targeted or delivered locally by means of heated pads or delivered to a patient’s whole body. Whole body hyperthermia is a very intensive procedure and must be delivered with skill and experience.
Our colleagues also utilise other heat producing non-radiation methods of hyperthermia including microwave heating equipment & radiofrequency (RF) capacitive heating equipment.
Proton Beam Therapy as a targeted heat delivery treatment:
Another very advanced high-tech heat therapy is Proton beam therapy (PBT) a type of radiotherapy.
PBT uses tiny parts of atoms called protons instead, rather than photons. Protons are better at precisely targeting a tumour. The energy hits mainly the tumour site and, unlike photons, does not deliver a dose beyond the tumour. This means there is less damage to healthy tissue and it’s thought that it causes fewer side effects.
It has also been reported that proton beam therapy has superior physical dose distribution profiles, as compared to conventional radiotherapy.
If you would like to inquire how hyperthermia, cell- based immune therapy and or proton beam therapy can help you Please Contact Grace
The Cancer Navigator fills many roles for patients seeking immune therapies, hyperthermia, proton beam therapy and other advanced cancer technologies – overseas.
Organise responsible case managed travel and treatment to give you the best options and therapeutic edge for surviving and thriving after cancer.
* Immunotherapy is also suitable for cancer survivors:
Conventional cancer treatments can sometime leave Survivors with long term health issues in particular compromised immunity – especially the part of the immune system that creates and hosts our cancer fighting cells e.g. NK cells, T-cells and dendritic cells.
Personalised immune therapies that can boost your own immune system by using your own white cells make a lot of sense. Of course, we have scoured the world for the best immune therapy doctors with longevity in the field. Not all cell vaccines are the same and not all doctors are experienced and qualified – so I advise caution.
Once again – we strongly advise that that you DO NOT try to do your own research and self-refer.
We recommend that patients always travel with a family member when embarking upon cancer treatment overseas.
The benefits of adding cancer vaccines & hyperthermia to your other treatment protocols.
*You can value add 25%- 35% effectiveness to other treatments by using immunotherapy. since 2004 until now our colleagues cite more than 5000 patients who have been administered with their own NK cells, CTLs, DCs etc.
*For example – between July 2005 and November 2013 – 1,939 patients with advanced or recurrent cancer were treated using hyperthermia and or immunotherapy. Standard therapy showed no effect or was refused by these patients.
*There were 309 (15.9%) patients who experienced a clinical benefit (complete response [CR], partial response [PR], and long-term stable disease [SD], >6 months), including 52 CR cases.
*The effective rate of immunotherapy increased from 9.9%to 19.1%using hyperthermia.
*The effective rate for patients with hyperthermia-alone was 3.6%, and skin and regional lymph node metastases disappeared. Immunotherapy alone was effective for liver or lung metastases.
Combined hyperthermia & immunotherapy had a beneficial effect on multiple metastases observed in important plural solid organs. Ovarian cancer – highest effective rate (25.0%), followed by prostate cancer.