Grace Gawler - Helping You Navigate the Cancer Maze

Genomic Radiation Sensitivity Testing

Genomic Radiation Sensitivity Testing

Genomic science can now solve the puzzle of why some cancer patients experience worse radiation side effects. 

The radiation sensitivity assay may help determine if you have the TGFβ1 genetic variation associated with a low or high risk of developing radiation fibrosis. There is no doubt that for some patients’ radiation therapy is lifesaving and life extending, however side effects – both short and long term, can cause cancer patients significant suffering.

The impact of life changing side effects can impact physical and psychological wellbeing. Side effects such as discussed on this page, especially in cancer patients over 60 years of age, should be taken into account. Short or long term debilitation may be able to be avoided. 

Causes of Radiation Induced Fibrosis

Why consider Radiation Sensitivity Testing?

Genomic Testing can determine if you have the TGFβ1 genetic variation which may be associated with low or high risk of developing fibrosis.

Transforming growth factor-b1 (TGFβ1) is the major cytokine responsible for the regulation of fibroblast proliferation and differentiation. (Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells).

It has been suggested that an increase in these fibroblasts may trigger the development of fibrosis.  Contact GRACE

Around 50% of patients with solid malignant tumours receive radiation therapy at some point in the course of their disease.