The Grace Gawler Institute supports pharmacovigilant practises for our Patients.
Pharmacovigilance is defined by the World Health Organization as the science and activity related to detecting, assessing, understanding and preventing adverse effects and other medicine-related problems. This is why we recommend that all our Navigated patients undertake pharmacogenomic testing (PGX).
The Right Drug, for the Right Patient, at the Right Dose…
When your doctor tells you that Pharmacogenomics (PGX) is new – here is what you need to know:
The history of pharmacogenetics stretches as far back as 510 b.c. when Pythagoras noted that ingestion of fava beans resulted in a potentially fatal reaction in some people, but not all, individuals. The question begged – Why?
Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the inter-individual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to tailor drugs to individuals based on their genetic makeup and molecular profile.
From early findings in the 1950s uncovering inherited deficiencies in drug metabolism that explained drug-related adverse events, to nowadays genome-wide approaches assessing genetic variation in multiple genes, pharmacogenomics has come a long way.
The evolution of pharmacogenomics has paralleled the evolution of genotyping technologies, the completion of the human genome sequencing and the HapMap project.
For just $450 you can be empowered to access pharmacogenomic (PGX) testing – your life may depend on it!
For information on how you can organise your PGX testing – Contact GRACE now!
The Pharmacogenomics (PGx) test is your one test for life. This new test will cover your metabolic response to medications at all stages in life. It can be referred back to at any time regardless of your age or health status.
Pharmacogenomics (PGx) is the analysis of how genes affect your response to drugs. As everyone has a unique genetic makeup, this can affect how you will respond or react to certain medications.
A medication or dose that works for one person may be ineffective or cause harmful side effects in another.
Using the results from PGx testing, health care providers can individualize drug therapy selection and dosages for patients based on their genetic makeup.
Testing patients prior to beginning treatment may help determine their response to certain drug classes and help avoid drugs that may be ineffective or cause harmful side effects.
For patients currently on treatment, it may identify new treatment options or identify why current treatments aren’t working.
THE GOOD NEWS!
Medical complications & interactions can be prevented with PGx tests: A PGx test can show if you may have a serious reaction to certain medical drugs, or combinations of medical drugs, for example; anaesthetics, pain management, antiobiotics etc. The test can also reveal how you metabolise complementary supplements. While undergoing treatment or surgery, without PGx knowledge, you may experience a complication or multiple complications causing harm or even death from ‘unexpected’ reactions.
Pharmacogenomics can save Lives! Pharmacogenomics is a break away from one size fits all medicine.
Potential Benefits: Using the results from PGx testing, health care providers can individualize drug therapy selection and dosages for patients based on their genetic makeup. Testing patients prior to beginning treatment may help determine their response to certain drug classes and help avoid drugs that may be ineffective or cause harmful side effects. For patients currently on treatment, it may identify new treatment options or identify why current treatments aren’t working.
Advantages of PGx testing may include:
• Decreasing and potentially eliminating the need for a “trial and error” approach to find effective therapy and dosages
• Decreasing the number of adverse drug reactions a patient experiences
• Saving patients time and money on ineffective medications
• Decreasing the amount of time patients are on medication
• Improving patient quality of life by finding effect treatments faster.
How you process different types of drugs:
• Variations in genes influence how quickly or how thoroughly individuals metabolise specific drugs. Individuals may be classed as a poor, intermediate, normal or ultra-rapid metaboliser for certain drugs.
• More than 75% of people have variations in drug metabolism that fall outside of what is regarded as “normal” metabolisers. In some cases, these differences can cause
significant side effects or mean the medication is ineffective.
In severe cases, side effects may be life threatening.