Pharmacogenomics - the Right Drug, for the Right Patient, at the Right Dose
The Grace Gawler Institute supports Pharmacovigilant practises for our Patients.
Pharmacovigilance is defined by the World Health Organization as the science and activity related to detecting, assessing, understanding and preventing adverse effects and other medicine-related problems.
This is why we recommend that all our Navigated patients undertake Pharmacogenomic testing (PGX).
Pharmacogenomics, a science which explores people’s drug response based on their genetic make-up and lifestyle, offers clinical tests to identify many of the differences in each person’s cytochrome P450 enzymes, so that the correct drug, amount and frequency may be prescribed from the start for maximum beneficial effects with minimum side-effects.
Pharmacogenomics (PGx) – Your one test for life
When your doctor tells you that Pharmacogenomics (PGX) is too new, here is what you need to know:
The history of pharmacogenetics stretches as far back as 510 BC when Pythagoras noted that ingestion of fava beans resulted in a potentially fatal reaction in some people, but not all, individuals. The question begged – Why?
Pharmacogenomics and its predecessor pharmacogenetics study the contribution of genetic factors to the inter-individual variability in drug efficacy and safety. One of the major goals of pharmacogenomics is to tailor drugs to individuals based on their genetic makeup and molecular profile.
From early findings in the 1950s uncovering inherited deficiencies in drug metabolism that explained drug-related adverse events. Pharmacogenomics is considered during the design of clinical drug trials.
For just $450 you can be empowered to access pharmacogenomic (PGX) testing – your life may depend on it! Contact GRACE now!
Your one test for life
The Pharmacogenomics (PGx) test is your one test for life. This new test will cover your metabolic response to medications at all stages in life. It can be referred back to at any time regardless of your age or health status. Pharmacogenomics is a break away from one size fits all medicine.
When you receive your Pharmacogenomics report (34 pages) there is a summary card listed on the last page. The summary card should be printed and kept in your wallet or purse and provided to all treating health professionals, including anaesthetists, dentists, GP, pharmacists, oncologists, et cetera.
Potential Benefits: With PGx results doctors can individualize drug selection and dosage for patients based on genetic makeup. Testing patients before treatment may help determine response to certain drugs helping to avoid drugs that may be ineffective or cause harmful side effects. For patients currently on treatment, results may identify better treatment options or identify why a patient is experiencing side-effects.
Optimising patient care with Pharmacogenomics
Advantages of PGx testing may include:
• Decreasing and potentially eliminating the need for a “trial and error” approach to find effective therapy and dosages
• Decreasing the number of adverse drug reactions a patient experiences
• Saving patients time and money on ineffective medications
• Decreasing the amount of time patients are on medication
• Improving patient quality of life by finding effect treatments faster.
How you process different types of drugs:
• Variations in genes influence how quickly or how thoroughly individuals metabolise specific drugs. Individuals may be classed as a poor, intermediate, normal or ultra-rapid metaboliser for certain drugs.
• More than 75% of people have variations in drug metabolism that fall outside of what is regarded as “normal” metabolisers. In some cases, these differences can cause significant side effects or mean the medication is ineffective.
In severe cases, side effects may be life threatening.